The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

A spirited princess with the heart of a warrior embarks on a mission to fulfill an ancient prophecy and save humanity from the wrath of vengeful gods.

Follows the surreal adventures of a cow, named Cow, and her chicken brother, named Chicken. They are often antagonized by "The Red Guy", who poses as various characters to scam them.