The Sons of Anarchy (SOA) are an outlaw motorcycle club with many charters in the United States and overseas. The show focused on the original and founding charter, Sons of Anarchy Motorcycle Club, Redwood Original, often referred to by the acronym SAMCRO, Sam Crow, or simply Redwood Charter. The charter operates both legal and illegal businesses in the small town of Charming, California. They combine gun-running and a garage, and involvement in porn film industry. Clay, the charter president, likes it old school and violent; while Jax, his stepson and the club's VP, has thoughts about changing the way things are done. Their conflict has effects on both the club and their personal relationship, especially when Jax goes on a personal quest to cleanse the SAMCRO name and image.

Traces over three generations an immigrant family's trials, tribulations, tragedies, and triumphs. Maria and Jose, the first generation, come to Los Angeles, meet, marry, face deportation all in the 1930s. They establish their family in East L.A., and their children Chucho, Paco, Memo, Irene, Toni, and Jimmy deal with youth culture and the L.A. police in the '50s. As the second generation become adults in the '60s, the focus shifts to Jimmy, his marriage to Isabel (a Salvadorian refugee), their son, and Jimmy's journey to becoming a responsible parent.