Bored with life and considering the real world to be just a “crappy game,” savvy sibling shut-ins Sora and Shiro have withdrawn into their own fantasy world filled with video games. However, one day they find themselves summoned to another world by a boy who calls himself “God,” their abilities are about to be put to the ultimate test! Now not only their fates — but the fate of all of humanity — will be decided by a series of games that may just be the hardest these super-geniuses have ever faced!

Alcohol, smoking, and stress—in the body subjected to these irritants, the cells responsible for maintaining life seem to fight a war that never ends. Due to a severe shortage of workers, Red Blood Cell AA2153 has to quickly learn to deliver oxygen and collect carbon dioxide, even in dangerous conditions. Meanwhile, White Blood Cell U-1196 has to do her part by dealing with germs and viruses during life-threatening situations. In the midst of these crises, they have to work together to keep the body healthy, despite not knowing if their sacrifices will be worthwhile. Cells at Work! Code Black takes a different approach by showing the grittier side of the jobs our cells perform.