Sakaido is a genius detective who can track down any criminal. But when his daughter is murdered, revenge lands him on the other side of the law. Now in prison, he helps the police solve mysteries using a system that invades a person’s identity. Little by little, a trail of blood forms, and it all leads back to his daughter’s murderer.

Alcohol, smoking, and stress—in the body subjected to these irritants, the cells responsible for maintaining life seem to fight a war that never ends. Due to a severe shortage of workers, Red Blood Cell AA2153 has to quickly learn to deliver oxygen and collect carbon dioxide, even in dangerous conditions. Meanwhile, White Blood Cell U-1196 has to do her part by dealing with germs and viruses during life-threatening situations. In the midst of these crises, they have to work together to keep the body healthy, despite not knowing if their sacrifices will be worthwhile. Cells at Work! Code Black takes a different approach by showing the grittier side of the jobs our cells perform.